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Structure of the compounds. Bioprecursors are TE4a, TE4gt, and TE3. Upon action of esterases (Nu:), S-CO bonds of thioester (TE4a and TE4gt) and of thiocarbonate (TE3) of prodrugs break and generate stable thiazolium cycle with loss of hydroxyl ion. TM1 is a compound that is stable under esterase action.
