Table 2. Ranking of the top 50 network nodes after seeding with 157 genes from whole genome AD linkage scan.

Rank*	Sec. ev.	P valuer	SP ID	Symbol	P valuets	MLS	Rank	Sec. ev.	P valuer	SP ID	Symbol	P valuets	MLS
1	179.29	0.0002	P08047	SP1	0.1066		26	168.52	0.0031	P38936	CDKN1A	0.1343
2	179.24	0.0002	P03372	ESR1	0.1511		27	167.73	0.0036	Q09472	EP300	0.1786
3	178.27	0.0003	P12931	SRC	0.1340		28	167.53	0.0037	P42224	STAT1	0.1631
4	178.22	0.0003	P20132	SDS	0.1680		29	167.45	0.0038	P31749	AKT1	0.0671
5	176.20	0.0005	P29323	EPHB2	0.0706		30	167.31	0.0039	Q05397	PTK2	0.0554
6	174.31	0.0009	P01106	MYC	0.2409		31	166.92	0.0041	Q13510	ASAH1	0.0091
7	173.20	0.0012	P16220	CREB1	0.0237		32	166.91	0.0042	P29354	GRB2	0.0957
8	172.72	0.0013	P04637	TP53	0.4100		33	166.45	0.0045	P35568	IRS1	0.0743
9	172.31	0.0014	P43320	CRYBB2	0.0463		34	165.73	0.0051	P04049	RAF1	0.1737
10	172.20	0.0015	P00750	PLAT	0.0086		35	165.59	0.0052	P14222	PRF1	0.1111	1.8
11	171.98	0.0015	Q92793	CREBBP	0.0871		36	165.43	0.0054	P02248	UBB	0.3763
12	171.90	0.0016	P28482	MAPK1	0.0929		37	164.56	0.0062	P98160	HSPG2	0.1000
13	171.70	0.0016	P21912	SDHB	0.0746		38	164.42	0.0063	O00688	EGFR	0.3160
14	171.21	0.0018	P02593	CALM3	0.0397	7.7	39	164.21	0.0065	Q06124	PTPN11	0.1871
15	171.21	0.0018	P20226	TBP	0.0306	2.2	40	164.10	0.0067	P06400	RB1	0.3969
16	171.04	0.0019	Q14155	P85	0.1043		41	163.48	0.0074	P15498	VAV1	0.0437
17	170.79	0.0020	P08100	RHO	0.0523		42	162.77	0.0082	P05231	IL6	0.0466
18	170.31	0.0022	P01133	EGF	0.2280		43	162.68	0.0083	Q07869	PPARA	0.2077
19	169.74	0.0024	P17080	RAN	0.0020		44	162.64	0.0084	P42858	HD	0.0837
20	169.33	0.0026	P01375	TNF	0.3089		45	162.63	0.0084	P06744	GPI	0.0051
21	169.07	0.0028	P40763	STAT3	0.0766		46	162.48	0.0086	P06241	FYN	0.2217
22	169.04	0.0028	P29353	SHC1	0.0643		47	162.41	0.0087	Q92940	MADH3	0.0971
23	169.03	0.0028	P11498	PC	0.0243		48	162.23	0.0089	P05549	TFAP2A	0.1754
24	169.02	0.0028	P27361	MAPK3	0.0800		49	161.92	0.0093	O60674	JAK2	0.1151
25	168.62	0.0030	P12004	PCNA	0.2600		50	161.88	0.0094	P06401	PGR	0.0711

Bold, nodes with primary evidence; italics, AD expert genes; P value_r, raw P value; P value_ts, topology-subtracted P value; SP ID, Swiss Prot identifier; Sec. ev., secondary evidence value.

^*Sorted by raw P values.