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. 2004 Oct 7;101(42):15148–15153. doi: 10.1073/pnas.0404315101

Table 2. Ranking of the top 50 network nodes after seeding with 157 genes from whole genome AD linkage scan.

Rank* Sec. ev. P valuer SP ID Symbol P valuets MLS Rank Sec. ev. P valuer SP ID Symbol P valuets MLS
1 179.29 0.0002 P08047 SP1 0.1066 26 168.52 0.0031 P38936 CDKN1A 0.1343
2 179.24 0.0002 P03372 ESR1 0.1511 27 167.73 0.0036 Q09472 EP300 0.1786
3 178.27 0.0003 P12931 SRC 0.1340 28 167.53 0.0037 P42224 STAT1 0.1631
4 178.22 0.0003 P20132 SDS 0.1680 29 167.45 0.0038 P31749 AKT1 0.0671
5 176.20 0.0005 P29323 EPHB2 0.0706 30 167.31 0.0039 Q05397 PTK2 0.0554
6 174.31 0.0009 P01106 MYC 0.2409 31 166.92 0.0041 Q13510 ASAH1 0.0091
7 173.20 0.0012 P16220 CREB1 0.0237 32 166.91 0.0042 P29354 GRB2 0.0957
8 172.72 0.0013 P04637 TP53 0.4100 33 166.45 0.0045 P35568 IRS1 0.0743
9 172.31 0.0014 P43320 CRYBB2 0.0463 34 165.73 0.0051 P04049 RAF1 0.1737
10 172.20 0.0015 P00750 PLAT 0.0086 35 165.59 0.0052 P14222 PRF1 0.1111 1.8
11 171.98 0.0015 Q92793 CREBBP 0.0871 36 165.43 0.0054 P02248 UBB 0.3763
12 171.90 0.0016 P28482 MAPK1 0.0929 37 164.56 0.0062 P98160 HSPG2 0.1000
13 171.70 0.0016 P21912 SDHB 0.0746 38 164.42 0.0063 O00688 EGFR 0.3160
14 171.21 0.0018 P02593 CALM3 0.0397 7.7 39 164.21 0.0065 Q06124 PTPN11 0.1871
15 171.21 0.0018 P20226 TBP 0.0306 2.2 40 164.10 0.0067 P06400 RB1 0.3969
16 171.04 0.0019 Q14155 P85 0.1043 41 163.48 0.0074 P15498 VAV1 0.0437
17 170.79 0.0020 P08100 RHO 0.0523 42 162.77 0.0082 P05231 IL6 0.0466
18 170.31 0.0022 P01133 EGF 0.2280 43 162.68 0.0083 Q07869 PPARA 0.2077
19 169.74 0.0024 P17080 RAN 0.0020 44 162.64 0.0084 P42858 HD 0.0837
20 169.33 0.0026 P01375 TNF 0.3089 45 162.63 0.0084 P06744 GPI 0.0051
21 169.07 0.0028 P40763 STAT3 0.0766 46 162.48 0.0086 P06241 FYN 0.2217
22 169.04 0.0028 P29353 SHC1 0.0643 47 162.41 0.0087 Q92940 MADH3 0.0971
23 169.03 0.0028 P11498 PC 0.0243 48 162.23 0.0089 P05549 TFAP2A 0.1754
24 169.02 0.0028 P27361 MAPK3 0.0800 49 161.92 0.0093 O60674 JAK2 0.1151
25 168.62 0.0030 P12004 PCNA 0.2600 50 161.88 0.0094 P06401 PGR 0.0711

Bold, nodes with primary evidence; italics, AD expert genes; P valuer, raw P value; P valuets, topology-subtracted P value; SP ID, Swiss Prot identifier; Sec. ev., secondary evidence value.

*

Sorted by raw P values.