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. Author manuscript; available in PMC: 2017 Jan 13.
Published in final edited form as: Cancer Prev Res (Phila). 2014 Aug 4;7(10):1023–1034. doi: 10.1158/1940-6207.CAPR-14-0140

Figure 2. Predictive value of molecular markers for distinguishing case from control adenomas.

Figure 2

In (a), is shown a receiver operating curve (ROC) for ability of a panel of molecular markers of carcinogenesis including p53, BCAT, MGMT, DNApcks, p21, Cox-2, and survivin to distinguish adenomas from high risk case patients with CRC from low risk control patients without CRC. The ROC demonstrates substantial predictive ability, AUC=0.83, 95% CI (0.74 -0.92). In (b), is shown a ROC for a parsimonious, 3 marker panel, with DNApkcs, MGMT, and p21 for prediction of case adenoma status. The ROC demonstrates substantial predictive ability, AUC=0.84, 95% CI: (0.74 – 0.92). BCAT, beta catenin; DNApkcs, DNA dependent protein kinase; MGMT, 0(6)-methylguanine-DNA methyltransferase.