Table 3.
Differences in gene expression in the dorsolateral prefrontal cortex (DLPFC, area 46) between schizophrenia (SZ) and control (NC) brains.
| Gene name | Identifier | Average expression change in SZ | Significance (P value) | Name and function(s) |
|---|---|---|---|---|
| SZ vs NC: DLPFC (area 46) left side only | ||||
| KRT18 | 4028716 | −1.81 | 0.040313* | Keratin 18; intermediate filament involved in poly(A) RNA binding, scaffold protein binding and filament reorganization; its promotor is responsive to EGFR activation |
| XGY2 | 4028512 | −1.75 | 0.007113** | XG pseudogene on Y chromosome; function unknown |
| DDX3Y | 4030162 | −1.68 | 0.010251* | RNA helicase on Y chromosome; involved in RNA splicing, cell cycle, apoptosis and differentiation |
| TTTY15 | 4030063 | −1.55 | 0.024267* | Testis-specific transcript on Y chromosome; non-coding RNA, function unknown |
| RPS13 | 3364736 | −1.51 | 0.006037** | Ribosomal protein S13; involved in poly(A) RNA binding and mRNA binding |
| ACTA2 | 3299504 | −1.50 | 0.012868* | Actin a2; recently described mutations support the role in development of frontal lobe, cingulate gyrus, corpus callosum and cerebellum |
| KAT7 | 3725964 | 1.49 | 0.005552** | Lysine acetyltransferase 7; forms histone acetyltransferase (HAT) complex |
| USP22 | 3749728 | 1.49 | 0.001972** | Ubiquitin-specific peptidase 22; a histone deubiquitinating component of the transcription regulatory HAT complexes, such as SAGA (Spt/Ada/Gcn5L acetyltransferase) |
| GDI2# | 3275374 | 1.50 | 0.011052* | GDP dissociation inhibitor 2; involved in vesicular trafficking of molecules between cellular organelles and G-protein coupled receptors (GPCR) signalling (such as dopamine receptors) |
| SEPT2# | 2536335 | 1.51 | 0.000687*** | Septin 2; involved in GTP binding and ERK signalling; may also play a role in the internalization of intracellular microbial pathogens (e.g. Listeria monocytogenes and Shigella flexneri) |
| SEPT2# | 2536333 | 1.51 | 0.002780** | Septin 2; involved in GTP binding and EGFR signalling; may also play a role in the internalization of intracellular microbial pathogens |
| NPM1# | 2840668 | 1.51 | 0.002012** | Nucleophosmin; involved in ribosome biogenesis, protein chaperoning, histone assembly and many other functions with multiple binding partners |
| SNX3 | 2968446 | 1.52 | 0.001712** | Sorting nexin 3 protein; involved in endosome trafficking and interacts with PtdIns3P |
| NPM1# | 2840726 | 1.54 | 0.011123* | Nucleophosmin; involved in ribosome biogenesis, protein chaperoning, histone assembly and many other functions with multiple binding partners |
| GDI2* | 3275252 | 1.54 | 0.017255* | GDP dissociation inhibitor 2; involved in vesicular trafficking of molecules between cellular organelles and G-protein coupled receptors (GPCR) signaling (such as dopamine receptors) |
| unconfirmed | 3275254 | 1.59 | 0.002173** | Probably a non-protein coding RNA |
| unconfirmed | 3275188 | 1.63 | 0.002547** | Probably a non-protein coding RNA |
| TARDBP | 2320116 | 1.73 | 0.006721** | Transactive response DNA binding protein; bind both DNA and RNA and have multiple functions in transcriptional repression (e.g. represses HIV-1 transcription), pre-mRNA splicing and translational regulation; hyperphosphorylated, ubiquinated and cleaved form (TDP-43 protein) is the major disease protein in FTLD-TDP and ALS. |
|
| ||||
| SZ vs NC: DLPFC (area 46) right side only | ||||
| No significant changes with a 1.5 fold expression level cut-off | ||||
Table legend: EGFR, epidermal growth factor receptor; FTLD-TDP, frontotemporal lobar degeneration due to TDP-43-positive neuronal inclusions; GDP, guanosine diphosphate; GTP, guanosine triphosphate; TDP-43, transactive response DNA protein of 43 kDa; *P . 0.05, **P . 0.01, ***P . 0.001, ****P . 0.0001. Genes marked with # are different splicing variants of the same gene.