Table 4.
Differences in gene expression in the MOFC (area 11/12) between schizophrenia (SZ) and control (NC) brains.
| Gene name | Identifier | Average expression change in SZ | Significance (P value) | Name and function(s) |
|---|---|---|---|---|
| SZ vs NC: MOFC (area 11/12) left side only | ||||
| GDI2* | 3275388 | 1.76 | 0.000033**** | GDP dissociation inhibitor 2; involved in vesicular trafficking of molecules between cellular organelles and G-protein coupled receptors (GPCR) signaling (such as dopamine receptors) |
| CBX3 | 2993696 | 1.52 | 0.000032**** | Chromobox protein homolog 3; a heterochromatin protein that can bind DNA and lamin; it is recruited to sites of DNA damage and binds to histone H3 tails (thus can be involved in transcriptional reprogramming) |
| SNX3 | 2968446 | 1.62 | 0.000893*** | Sorting nexin 3 protein; involved in endosome trafficking and interacts with PtdIns3P |
| SART1 | 3335846 | 1.64 | 0.001175** | Squamous cell carcinoma antigen recognized by T-cells 1; protein involved in RNA splicing and pre-mRNA processing |
| STARD7 | 2565180 | 1.63 | 0.009539** | StAR-related lipid transfer domain protein 7; lipid transporter that specifically bind and transports phosphatidylcholine between membranes |
| GDI2* | 3275252 | 1.58 | 0.002656** | GDP dissociation inhibitor 2; involved in vesicular trafficking of molecules between cellular organelles and G-protein coupled receptors (GPCR) signaling (such as dopamine receptors) |
| SLC25A3 | 3427855 | 1.53 | 0.003733** | Solute carrier family 25 member 3; catalyzes the transport of phosphate into the mitochondrial matrix |
| ANAPC5 | 3475146 | 1.51 | 0.003543** | Anaphase promoting complex subunit 5; a large E3 ubiquitin ligase required for the proper ubiquitination; also controls cell cycle progression and interacts with poly (A) binding protein and represses internal ribosome entry site-mediated translation |
| HNRNPC | 3556086 | 1.50 | 0.002927** | Heterogeneous nuclear ribonucleoprotein C; involved in pre-mRNA processing, mRNA transport and metabolism |
| C1D | 2557627 | 1.59 | 0.013190* | Nuclear nucleic acid-binding protein C1D; apoptosis-inducing and DNA binding protein |
| XGY2 | 4028512 | −1.58 | 0.031729* | XG pseudogene on Y chromosome; function unknown |
| unconfirmed | 3275188 | 1.57 | 0.012645* | Probably a non-protein coding RNA |
| EVI2A | 3752271 | −1.56 | 0.024747* | Ecotropic viral integration site 2A; protein involved in transmembrane signaling receptor receptor activity |
| NPM1 | 2840726 | 1.51 | 0.010982* | Nucleophosmin; involved in ribosome biogenesis, protein chaperoning, histone assembly and many other functions with multiple binding partners |
| SZ vs NC: mOFC (area 11/12) right side only | ||||
| CANX | 2844385 | 1.48 | 0.006169** | Calnexin; a chaperone protein involved in ensuring that only properly folded and assembled proteins proceed along the secretory pathway of endoplasmatic reticulum and Golgi apparatus |
Table legend: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. #Genes under identifiers 3275252 and 3275388 are different splicing variants of the same GDI2 gene.