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. 2017 Jan 9;12:381–393. doi: 10.2147/IJN.S120902

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© 2017 Tang et al. This work is published and licensed by Dove Medical Press Limited

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Scheme 2 — Schematic illustration of the structure of OI-NP–mediated PSDT for MH7A cells. Liquid-gas transition and photodynamic reaction occurred in the OI-NPs under laser irradiation. The phase-transited OI-NPs were ruptured when exposed to low-intensity focused ultrasound and it caused a sonodynamic reaction.

Abbreviations: OI-NPs, oxygen and indocyanine green loaded nanoparticles; PDT, photodynamic therapy; RA-FLSs, rheumatoid arthritis fibroblast-like synoviocytes; SDT, sonodynamic therapy; US, ultrasound.