Table 1.

Affinities of (−)-stepholidine for a variety of receptors and other drug targets as documented in the PDSP database

Receptor/target	Ki (nM)	Receptor/target	Ki (nM)
SERT	>10,000	M2	>10,000
5-HT1A	143.4	M5	>10,000
5-HT1B	6,984	D1	5.9
5-HT1D	>10,000	D2	974.3
5-HT1E	>10,000	D3	30.1
5-HT2A	>10,000	D4	3,748
5-HT2B	226	D5	4.4
5-HT2C	>10,000	DAT	>10,000
5-HT3	>10,000	GABA-A	>10,000
5-HT5	>10,000	Glutamate-NMDA	>10,000
5-HT6	>10,000	H1	>10,000
5-HT7	>10,000	H2	>10,000
Alpha1A	>10,000	H3	>10,000
Alpha1B	>10,000	H4	>10,000
Alpha2A	>10,000	Imidazoline-1	8,909
Alpha2B	6,884	NET	>10,000
Alpha2C	214.5	DOR	>10,000
Beta1	>10,000	KOR	>10,000
Beta2	>10,000	MOR	>10,000
Calcium channel	>10,000	Sigma-1	1,600
CB1	>10,000	Sigma-2	53.4
CB2	>10,000

Affinity (Ki) determinations were obtained from the National Institute of Mental Health’s Psychoactive Drug Screening Program (PDSP). For experimental details please refer to the PDSP web site: http://pdsp.med.unc.edu/. Ki values >10,000 nM showed no or minimal displacement of an orthosteric radioligand at the highest concentration tested. Ki values between 1 and 10 μM are indicated in boldface whereas Ki values that are less than 1 μM are indicated in italics