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LD metabolism and place of action of OPC.
Abbreviations: 3-MT, 3-methoxy-tyramine; 3-OMD, 3-O-methyldopa; AADC, aromatic amino acid decarboxylase; BBB, blood–brain barrier; COMT, catechol-O-methyltransferase; DA, dopamine; DOPAC, 3,4-dihydroxy-phenylacetic acid; HVA, homovanillic acid; LD, levodopa; MAO, monoamine oxidase; OPC, opicapone.
