TABLE 1.
Plasma parameters in C57BL/6 mice treated with ASO-ctrl or ASO-Fsp27
| Diet Treatment | ND | HFD ASO-ctrl | HFD ASO-Fsp27 |
| N | 4 | 6 | 6 |
| Triglyceridesa (mg/dl) | 54.4 ± 2.6 | 58.0 ± 8.2 | 35.1 ± 2.6b,c |
| Cholesterola (mg/dl) | 104.2 ± 17.2 | 189.8 ± 5.8d | 207.9 ± 8.7d |
| FFAa (mM) | 0.15 ± 0.02 | 0.19 ± 0.02 | 0.20 ± 0.02 |
| Glucosea (mg/dl) | 126.0 ± 5.1 | 170.4 ± 4.2d | 156.0 ± 4.7d |
| Glucosee (mg/dl) | 57.3 ± 4.6 | 112.4 ± 2.7d | 96.6 ± 6.8d |
| Insulina (ng/ml) | 0.75 ± 0.32 | 3.09 ± 0.88b | 1.91 ± 0.71b |
| ASTa (mU/ml) | 13.8 ± 1.0 | 17.3 ± 1.5 | 13.9 ± 0.9 |
| ALTa (mU/ml) | 0.69 ± 0.02 | 1.11 ± 0.14b | 1.19 ± 0.14b |
Mice were fed ND or HFD and treated with ASOs as shown in Fig. 1A. Data are expressed as mean ± SEM.
a
Six hours food removal.
b
P ≤ 0.05 HFD vs. ND.
c
P ≤ 0.05 ASO-Fsp27 vs. ASO-ctrl.
d
P ≤ 0.01 HFD vs. ND.
e
Fasted overnight.