TABLE 2.
Physiologic parameters in ob/ob mice treated with ASO-ctrl or ASO-Fsp27
| ASO-ctrl | ASO-Fsp27 | |
| N | 6 | 6 |
| Food intake (Kcal/day) | 18.3 ± 0.4 | 17.4 ± 1.3 |
| Plasma TAGa (mg/dl) | 58.3 ± 5.6 | 53.4 ± 1.8 |
| Plasma cholesterola (mg/dl) | 189.4 ± 8.9 | 182.9 ± 7.8 |
| Plasma FFAa (mM) | 0.25 ± 0.02 | 0.24 ± 0.03 |
| Plasma glucosea (mg/dl) | 256.5 ± 29.5 | 248.5 ± 15.4 |
| Plasma glucoseb (mg/dl) | 101.6 ± 6.6 | 84.0 ± 3.9c |
| Plasma insulina (ng/ml) | 11.6 ± 1.2 | 11.5 ± 1.5 |
| Plasma ASTa (mU/ml) | 25.7 ± 3.1 | 26.9 ± 2.6 |
| Plasma ALTa (mU/ml) | 0.38 ± 0.08 | 0.43 ± 0.05 |
Mice were fed chow and treated as shown in Fig. 3A. Data are expressed as mean ± SEM.
a
Six hours food removal.
b
Fasted overnight.
c
P ≤ 0.05.