TABLE 2.
Characterization of cardiac function by MRI in WT and VLCAD−/− mice either under control or triheptanoin diet
| WT | VLCAD−/− | |||
| Control | C7 | Control | C7 | |
| Heart rate (bpm) | 579 ± 70 | 440 ± 31 | 569 ± 50 | 470 ± 32 |
| Cardiac output (ml/min) | 23.7 ± 3.5 | 17.7 ± 2.1 | 21.5 ± 3.7 | 19 ± 2.9 |
| End-diastolic volume (µl) | 57 ± 11.1 | 54 ± 10.2 | 61.8 ± 12 | 66.5 ± 19.3 |
| End-systolic volume (µl) | 15.8 ± 6.6 | 13.6 ± 4.3 | 24.1 ± 8.7a | 25.7 ± 12.33a |
| Stroke volume (µl) | 41.2 ± 5.7 | 40.4 ± 6 | 37.7 ± 5.1 | 40.8 ± 7 |
| Ejection fraction (%) | 73.3 ± 8.1 | 75.2 ± 3.1 | 62.1 ± 7.8a | 63.4 ± 7.7a |
| Left ventricular mass (mg) | 140.4 ± 11 | 109.7 ± 37.4b | 136.1 ± 10.9 | 146.8 ± 29.4a |
| Heart/body weight ratio | 4.45 ± 0.4 | 3.96 ± 1.3 | 4.67 ± 0.25 | 4.87 ± 0.6 |
| Wall thickness, diastole (mm) | 1.04 ± 0.11 | 0.94 ± 0.13 | 1.09 ± 0.08 | 1.08 ± 0.1 |
| Wall thickness, systole (mm) | 1.72 ± 0.28 | 1.53 ± 0.21 | 1.52 ± 0.14a | 1.53 ± 0.12 |
Values are mean ± SD (n = 10–12).
a
Significant differences (P < 0.05, two-way ANOVA and Student’s t-test) between WT and VLCAD−/− mice under the same dietary regimen.
b
Significant differences (P < 0.05, two-way ANOVA and Student’s t-test) between mice of the same genotype under different dietary regimen.