TABLE 1.
Serum parameters of Ldah WT and KO mice
WT (n) | KO (n) | P | |
Corticosterone (ng/ml) | 97.26 ± 75.65 | 114.02 ± 80.13 | 0.35 |
(6) | (8) | ||
Testosterone (ng/ml) | 2.03 ± 1.97 | 1.1 ± 1.34 | 0.18 |
(7) | (6) | Chow diet, ad lib | |
Cholesterol (mg/dl) | 132.62 ± 30.05 | 137.87 ± 8.21 | 0.34 |
(6) | (6) | ||
HDL (mg/dl) | 97.85 ± 21.02 | 99.91 ± 5.04 | 0.41 |
(6) | (6) | ||
LDL (mg/dl) | 17.36 ± 3.17 | 17.62 ± 2.04 | 0.43 |
(6) | (6) | ||
TG (mg/dl) | 52.45 ± 25.24 | 64.34 ± 30.58 | 0.24 |
(6) | (6) | ||
NEFA (mmol/L) | 0.92 ± 0.23 | 0.99 ± 0.21 | 0.29 |
(6) | (6) | ||
B-Hb (mmol/L) | 0.18 ± 0.06 | 0.14 ± 0.03 | 0.08 |
(6) | (6) | 4 weeks 60% high-fat diet, ad lib | |
TG (mg/dl) | 84.02 ± 7.97 | 75.09 ± 9.21 | 0.11 |
(3) | (4) | ||
B-Hb (mmol/L) | 0.51 ± 0.17 | 0.49 ± 0.11 | 0.44 |
(3) | (4) | ||
Glucose (mg/dl) | 166.00 ± 12.31 | 171.88 ± 20.25 | 0.26 |
(6) | (9) | ||
Leptin (ng/ml) | 44.19 ± 7.29 | 44.54 ± 6.02 | 0.45 |
(6) | (9) | 21 weeks 60% high-fat diet, fasted | |
Cholesterol (mg/dl) | 68.49 ± 8.14 | 67.46 ± 3.78 | 0.38 |
(6) | (7) | ||
HDL (mg/dl) | 51.60 ± 3.86 | 51.20 ± 4.36 | 0.43 |
(6) | (7) | ||
LDL (mg/dl) | 5.50 ± 0.80 | 5.73 ± 0.31 | 0.25 |
(6) | (7) | ||
TG (mg/dl) | 65.38 ± 9.05 | 62.01 ± 10.84 | 0.28 |
(6) | (7) | ||
NEFA (mmol/L) | 1.93 ± 0.28 | 1.81 ± 0.41 | 0.28 |
(6) | (7) | ||
B-Hb (mmol/L) | 1.96 ± 0.41 | 2.19 ± 0.58 | 0.22 |
(6) | (7) | Fasted, cold-exposed |
Serum parameters measured in different experiments for WT and Ldah KO animals are reported. The number of animals of a certain genotype (n) used for each study is shown in parentheses. Measurements belonging to one experiment are grouped together, with different experiments being separated by double rules. The feeding state and, where applicable, additional treatments of animals in a given experiment are indicated in the last column. Student’s t-test was performed for statistical analysis. B-Hb, β-hydroxybutyrate; NEFA, nonesterified fatty acid.