Fig. 2.

Box-and-whisker plots illustrating liver function tests in carriers of distinct PNPLA3, TM6SF2, and MBOAT7 variants. Carriers of either PNPLA3 or TM6SF2 risk alleles present with increased AST and ALT activities (A and B for PNPLA3; D and E for TM6SF2). We did not detect any major effects of these variants on the GGT activities (C and F). The MBOAT7 polymorphism did not affect liver function tests. All tests were performed using ANOVA with post hoc tests or with Mann-Whitney U as appropriate. *P < 0.05 in post hoc tests.