TABLE 5.
Distribution of alleles and genotypes for TM6SF2 p.E167K and association tests with respect to steatosis grade
| TM6SF2 p.E167K allele/ genotype | Count of alleles/genotypes | |
| Steatosis grade <S2 (2N = 306) | Steatosis S2–S3 (2N = 334) | |
| [E] | 280 (0.92) | 287 (0.86) |
| [K] | 26 (0.08) | 47 (0.14) |
| [EE] | 130 (0.85) | 123 (0.74) |
| [EK] | 20 (0.13) | 41 (0.25) |
| [KK] | 3 (0.02) | 3 (0.01) |
| Association test | OR | P value |
| Armitage’s trend test | 1.539 | 0.003 |
| OR statistics | OR (95% CI) | P value |
| [K] ↔ [E] | 1.764 (1.063–2.927) | 0.026 |
| [KK] ↔ [EE] | 1.057 (0.209–5.336) | 0.946 |
| [KK] ↔ [EK + EE] | 0.915 (0.182–4.601) | 0.913 |
| [KK + EK] ↔ [EE] | 2.022 (1.153–3.544) | 0.001 |
CI, confidence interval; E, glutamic acid; K, lysine; p, protein (amino acid number); TM6SF2, transmembrane 6 superfamily member 2. [K] represents the steatosis risk allele. Allele and genotype frequency differences were assessed by chi2 test or by Armitage’s trend test as appropriate (https://ihg.gsf.de/cgi-bin/hw/hwa1.pl).