TABLE 3.
Metabolic parameters of Lp(a) in comparison to LDL
| Metabolic Parameters of Individuals Studies | Normolipemic Healthy Volunteers | FH Patient | ||||
| LDL | Lp(a) | LDL | Lp(a) | |||
| Number of volunteers | 12 | 1 | ||||
| Sex | Male | Male | ||||
| Age | 65 ± 13 | 16 | ||||
| Body weight (kg) | 66.3 ± 10.3 | 46 | ||||
| Plasma cholesterol (mg/dl) | 200.7 ± 31.7 | 521 | ||||
| Plasma triglycerides (mg/dl) | 120.8 ± 42.3 | 65 | ||||
| LDL-apoB (mg/dl) | 73.4 ± 11.4 | 253 | ||||
| Plasma Lp(a) (mg/dl) | 41.6 ± 32.7 | 17 | ||||
| Half-life (t/2) | 3.84 ± 0.62 | 3.93 ± 0.83 | 5.17 | 4.81 | ||
| FCR | 0.377 ± 0.077 | 0.260 ± 0.060 | 0.205 | 0.21 | ||
| Rate of LDL apoB synthesis (mg/kg/day) | 12.44 ± 2.09 | 23.44 | ||||
| Rate of Lp(a) synthesis (mg/kg/day)a | 4.60 ± 3.64 | 1.61 | ||||
| Percent intravascular pool | 64.2 ± 9.1 | 76.1 ± 7.7 | 69.4 | 71.6 | ||
125I-Lp(a) and 131I-LDL were injected simultaneously into 12 healthy individuals and the metabolic parameters were calculated from the die-away curves followed over 14 days. Values in the table are adapted from (59). See main text for details.
a
The units for Lp(a) synthesis refer to the entire Lp(a) Lp.