TABLE 4.
Lys and Lys-analogs that inhibit the assembly of Lp(a)
| Substance | IC50 (mmol/l) |
| Benzamidine | >100 |
| Serotonine | >100 |
| Glutamic acid | >100 |
| Taurine | 55 |
| N-ε-acetyl-Lys | 52 |
| Lys | 38 |
| p-Aminomethylbenzene-sulfonamide | 33 |
| Hydroxyproline | 25 |
| Proline | 21 |
| N-α-acetyl-Lys | 9.7 |
| Ornithine | 8.2 |
| Spermidine | 6.5 |
| Spermine | 5.4 |
| ε-Aminohexoic acid | 4.8 |
| γ-Aminobutyric acid | 2.1 |
| δ-Aminovaleric acid | 0.76 |
| Tranexamic acid | 0.65 |
Purified LDL and recombinant apo(a) were mixed and free apo(a) was separated from Lp(a) through ultracentrifugation. IC50 relates to the concentration of the substance that inhibits 50% of the assembly. Values are from (75).