. Author manuscript; available in PMC: 2017 Jan 13.

Published in final edited form as: ACS Chem Neurosci. 2015 Feb 20;6(4):681–692. doi: 10.1021/acschemneuro.5b00020

Table 4.

Stimulation of D5R Receptor Signaling by Biased D1R Agonists

compound	cAMP accumulation^a		β-arrestin recruitment^a
compound	EC₅₀ (nM)	E_max (% of DA)	EC₅₀ (nM)	E_max (% of DA)
dopamine	184.7 ± 57	100	13.6 ± 2.4	100
SKF38393	40.6 ± 3.9	77.4 ± 7.3	23.7 ± 5.8	42.9 ± 1.9
SKF83959	>10000	<5	3.7 ± 2	20.3 ± 1
SKF82957	0.17 ± 0.3	37.7 ± 2.6	0.82 ± 0.3	30.9 ± 1.1
SKF77434	80.8 ± 68.4	69.2 ± 7.3	29.9 ± 5.1	34.7 ± 1
SKF75670	0.019 ± 0.003	53.8 ± 8.5	5.5 ± 0.2	31.7 ± 0.6

EC₅₀ and E_max values were obtained from nonlinear regression analysis of individual dose–response curves for cAMP accumulation or β-arrestin recruitment as shown in Figure 6. Comparison to the control maximal response exhibited by dopamine (DA) derives the percent response (E_max) of a test compound.