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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: AAPS J. 2016 Mar 30;18(4):861–875. doi: 10.1208/s12248-016-9904-3

Fig. 7.

Fig. 7

Schematics of a proposed systems pharmacokinetic model for intracellular processing of ADCs, which highlights our current understanding about the determinants responsible for ADC activation in a cell