Table 3. List of B cell associated genes found to be differentially expressed within the particular group comparison.
Annotation data are from http://www.uniprot.org/ and http://www.genecards.org/. In Tacrolimus/Sirolimus comparison fold change was calculated from gene expression medians of all measured time-points in particular groups. In rejecting and non-rejecting patients only samples collected at later time points (M2, M3, M6 and M12) were used to calculate medians of gene expression.
| Name | Median fold change | Description | Relevant features | ||
|---|---|---|---|---|---|
| Tac x Sir | Rej x non-rej. | Pre-Tx x W3 | |||
| TCL1A | 13.8 | -4.8 | 62.9 | T-cell leukemia/lymphoma 1A | Involved in B cell receptor pathway. Expressed in naive B cells more than in memory B cells. Overexpression of TCL1A prolongs naive B cell survival. |
| IGHM | 7.9 | -4.8 | 9.29 | immunoglobulin heavy constant mu | Encodes the C region of the mu heavy chain of the IgM isotype. Expressed by naive B cells. |
| CD79A | 6.6 | -4.7 | 22.57 | CD79a molecule, immunoglobulin-associated alpha | Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of of antigen to the B-cell antigen receptor complex (BCR) which leads to antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. |
| IGLC | 6.2 | -5.3 | 1.52 | immunoglobulin lambda constant group | Encodes the Ig domain. |
| CD200 | 6.2 | -6.3 | 3.21 | CD200 molecule | Encodes the Ig domain. |
| IGHG1IGHG2IGHG3IGHG4 | 5.8 | -3.3 | 1.06 | immunoglobulin heavy constant gamma 1 | Encodes the Ig domain. |
| IGKC | 5.6 | -3.9 | 2.67 | immunoglobulin kappa constant | Encodes the Ig domain. |
| BLK | 5.3 | -3.7 | 10.98 | B lymphoid tyrosine kinase | Encodes a nonreceptor tyrosine-kinase involved in B-cell receptor signaling. |
| FCRL2 | 5.2 | -3.1 | 3.33 | Fc receptor-like 2 | Membrane protein belonging to FCRL family, expressed preferentially by memory B cells. |
| IGHA1 | 5.2 | -4.3 | 1.28 | immunoglobulin heavy constant alpha 1 | Ig domain. |
| MS4A1 | 4.9 | -5.0 | 15.9 | membrane-spanning 4-domains, subfamily A, member 1 | B-lymphocyte specific, cell-surface molecule involved in B cell activation and differentiation. |
| CD19 | 3.4 | -3.9 | 4.27 | CD19 molecule | Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. |