Fig 7. Model for entry and localization of B. pseudomallei in the nucleus of host cell.

[1] Entry of B. pseudomallei into the epithelial cell aided by the type III secretion system (TTSS), which induces the formation of membrane ruffles necessary for uptake of the bacteria, [2] B. pseudomallei escapes from the endosome into the cytoplasm of the cell, [3] B. pseudomallei replicate intracellularly in the cytoplasm of the host, [4] B. pseudomallei polymerizes host cell actin to form actin comet tails in order for it to mobilize within host cell cytoplasm, [5] B. pseudomallei enters the nucleus of host cell via actin comet tails, and [6] Localization of B. pseudomallei in the nucleus of the host, potentially in a dormant state.