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. Author manuscript; available in PMC: 2018 Jan 11.
Published in final edited form as: Cell Host Microbe. 2017 Jan 11;21(1):35–46. doi: 10.1016/j.chom.2016.12.010

Figure 5. Kinetics of the ZIKV-specific CD8+ T cell response in LysMCre+IFNARfl/fl mice.

Figure 5

LysMCre+IFNARfl/fl mice were infected with 104 FFU of ZIKV strain MR766 or FSS13025. Splenocytes were harvested at 3, 7, and 14 days post-infection and stimulated with immunodominant ZIKV-derived peptides to assess cytokine production by ICS. (A) The frequency of IFNγ-producing CD8+ T cells and (B) the frequency of CD44+CD62L− CD8+ T cells at day 3 (white), 7 (black), and 14 (grey) post-infection are shown. The background production of IFNγ obtained in MOCK was subtracted from all values. Two-way ANOVA test was used to compare the time points for each peptide (P > 0.05). The error bars correspond to SEM.