Fig. 2.

Pain-related behaviours are unchanged in mice lacking Gpr151.

A: baseline thermal withdrawal thresholds were similar in WT (open box) and Gpr151 MUT (filled box) mice. B: withdrawal thresholds to mechanical stimulation were tested 3 days before (BL3) and at several time points after spared nerve injury (SNI) for up to 28 days. No differences in pain-related withdrawal thresholds were observed between WT (n = 8) and Gpr151 MUT mice (n = 10) at any time point. C: mice were injected with 20 μl 1% formalin into the plantar hind paw and nocifensive behaviour monitored in 5 min bins for 1 h. There were no significant differences in pain-related behaviour between WT (n = 6) and Gpr151 MUT (n = 10) mice in the first (0–10 min) or second (10–60 min) phases of the test.