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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Transplantation. 2016 Oct;100(10):2062–2070. doi: 10.1097/TP.0000000000001214

Figure 2.

Figure 2

A comprehensive pathway/gene-set analysis using the software GO-Elite was performed to identified molecular pathways enriched in PVAN compared to TCMR. This resulted in enrichment of 2 distinct set of pathways. Immune system related pathways such as complement cascade, TCR signaling, innate immune system, adaptive immune system were specific to TCMR whereas PVAN associated genes were enriched with DNA replication pathways such as mRNA processing, ribosomal scanning, viral mRNA translation etc. and metabolic pathways such as urea cycle, gluconeogenesis, TCA cycle etc. were specific to PVAN demonstrating 2 distinct molecular events occurring at the time of TCMR and PVAN.