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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Transplantation. 2016 Oct;100(10):2062–2070. doi: 10.1097/TP.0000000000001214

Figure 4.

Figure 4

Using immunohistochemistry (IHC) validation of PVAN specific expression of LTF and IFITM1 in kidney biopsies with PVAN. We assessed the expression of 2 gene transcripts (LTF and IFITM-1) at the protein level. These transcripts were highly upregulated in kidney biopsies with PVAN as compared to TCMR and STA. A) Three representatives phenotypes from 3 representative transplant patient biopsies evaluated for the different protein stains. TCMR and STA are shown at 10× and the PVAN samples are shown at 40× magnification. Co-localization of IFITM-1 with BK viral inclusions are marked with yellow arrows in the PVAN patient. LTF also localizes in proximity to the SV40 and IFITM-1 stains in the renal tubule. (B) Semi quantitative analysis of protein expression at tubulo-epithelial cells (TEC) and mononuclear cells of patients with PVAN, TCMR and STA.