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. 2016 Sep 28;3(1):99–118. doi: 10.1016/j.jcmgh.2016.09.009

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© 2017 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

MEK inhibition diminishes levels of inflammatory cytokines during pancreatitis. (A) CP protocol with drug pretreatment. (B) Immunoblot array of cytokines present in pancreata or untreated mice or mice treated with cerulein and either vehicle or trametinib. (C) qRT-PCR analysis of inflammatory cytokines present in pancreata treated with cerulein and vehicle or trametinib. (D) CP protocol (No Dox) or shRNA activation during CP protocol (Dox). (E) qRT-PCR analysis of inflammatory cytokines present in cerulein with or without doxycycline-induced shMEK1/2. (F) Potential mechanism of amelioration of CP by MEK inhibition.