Table 1.

Strategies for sustained drug release from electrospun fibers.

Fiber architecture	Agent				Release (units)				Ref.
	Name	Loading wt.%	Aq. Sol.a (mg/mL)	Log Pa	1 h	24 h	7d	14d
Uniaxial Fibers
PLGA	Paclitaxel	10	<0.01	3.95	10%	22%	40%	50%	[54]
	Cefoxitin sodium	5	0.15	−0.92	70%	72%	80%	–	[37]
PLA	Tetracycline hydrochloride	5	0.46	−0.42b	35%	35%	35%	–	[77]
	Metronidazole	40	29	−0.14	5%	25%	45%	–	[64]
	Amoxicillin	7	0.58	0.88	10%	15%	20%	20%	[78]
PLLA	Paclitaxel	15	<0.01	3.95	0–1%	0–1%	–	–	[57]
	Doxorubicin hydrochloride	1.6	1.18b	1.41b	70%	87%	–	–	[57]
	Doxorubicin	1.6	0.41	0.24	20%	20%	–	–	[57]
Polyurethane	Itraconazole	40	<0.01	4.99	2ug/cm2	20ug/cm2	–	–	[36]
	Ketanserin	10	<0.01	3.56	2ug/cm2	10ug/cm2	–	–	[36]
Coaxial fibers  (core:shell Qc/Qs)
PEG:PBS 3/1	Triclosan	5	<0.01	5.34	75%	–	–	–	[75]
	Curcumin	5	0.05	3.07	90%	–	–	–	[75]
28%Zein:1%Zein 4/1	Ketoprofen	10	58	2.91	5%	100%	–	–	[79]
PCL:Gelatin 1/2	Metronidazole	33.4	29	−0.14	5%	60%	95%	100%	[76]
PCL:PVA 1/8	Metoclopramide hydrochloride	1	0.24b	2.36b	5%	55%	65%	68%	[68]
PLLA:PVA 1/8	Metoclopramide hydrochloride	1	0.24b	2.36b	2%	12%	22%	25%	[68]
PLGA:PVA 1/8	METOCLOPRAMIDE hydrochloride	1	0.24b	2.36b	5%	38%	62%	72%	[68]
PCL:PEG	Salicylic acid	10	1000	2.01	10%	25%	40%	–	[80]
PEG:PLA 1/4	Salicylic acid	15	1000	2.01	0.1 mg/mL	0.2 mg/mL	–	–	[70]
PEG:cellulose acetate and gelatin 1/2	Amoxicillin	3.7	0.58	0.88	22%	100%	–	–	[73]
PMMA:Nylon6 1/1	Ampicillin	20	0.87	1.48	100ug/mL	300ug/mL	600ug/mL	800ug/mL	[67]

^aScifinder, substance identifier: calculated using Advanced Chemistry Development (ACD/Labs) software v11.02; (accessed Jul 04, 2015).

^bDrugBank v4.3: calculated using ALOGPS v2.1; (accessed Jul 04, 2015).