Table 1.
Strategies for sustained drug release from electrospun fibers.
| Fiber architecture | Agent |
Release (units) |
Ref. | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | Loading wt.% | Aq. Sol.a
(mg/mL) |
Log Pa | 1 h | 24 h | 7d | 14d | ||
| Uniaxial Fibers | |||||||||
| PLGA | Paclitaxel | 10 | <0.01 | 3.95 | 10% | 22% | 40% | 50% | [54] |
| Cefoxitin sodium | 5 | 0.15 | −0.92 | 70% | 72% | 80% | – | [37] | |
| PLA | Tetracycline hydrochloride | 5 | 0.46 | −0.42b | 35% | 35% | 35% | – | [77] |
| Metronidazole | 40 | 29 | −0.14 | 5% | 25% | 45% | – | [64] | |
| Amoxicillin | 7 | 0.58 | 0.88 | 10% | 15% | 20% | 20% | [78] | |
| PLLA | Paclitaxel | 15 | <0.01 | 3.95 | 0–1% | 0–1% | – | – | [57] |
| Doxorubicin hydrochloride | 1.6 | 1.18b | 1.41b | 70% | 87% | – | – | [57] | |
| Doxorubicin | 1.6 | 0.41 | 0.24 | 20% | 20% | – | – | [57] | |
| Polyurethane | Itraconazole | 40 | <0.01 | 4.99 | 2ug/cm2 | 20ug/cm2 | – | – | [36] |
| Ketanserin | 10 | <0.01 | 3.56 | 2ug/cm2 | 10ug/cm2 | – | – | [36] | |
| Coaxial fibers (core:shell Qc/Qs) |
|||||||||
| PEG:PBS 3/1 | Triclosan | 5 | <0.01 | 5.34 | 75% | – | – | – | [75] |
| Curcumin | 5 | 0.05 | 3.07 | 90% | – | – | – | [75] | |
| 28%Zein:1%Zein 4/1 | Ketoprofen | 10 | 58 | 2.91 | 5% | 100% | – | – | [79] |
| PCL:Gelatin 1/2 | Metronidazole | 33.4 | 29 | −0.14 | 5% | 60% | 95% | 100% | [76] |
| PCL:PVA 1/8 | Metoclopramide hydrochloride | 1 | 0.24b | 2.36b | 5% | 55% | 65% | 68% | [68] |
| PLLA:PVA 1/8 | Metoclopramide hydrochloride | 1 | 0.24b | 2.36b | 2% | 12% | 22% | 25% | [68] |
| PLGA:PVA 1/8 | METOCLOPRAMIDE hydrochloride | 1 | 0.24b | 2.36b | 5% | 38% | 62% | 72% | [68] |
| PCL:PEG | Salicylic acid | 10 | 1000 | 2.01 | 10% | 25% | 40% | – | [80] |
| PEG:PLA 1/4 | Salicylic acid | 15 | 1000 | 2.01 | 0.1 mg/mL | 0.2 mg/mL | – | – | [70] |
| PEG:cellulose acetate and gelatin 1/2 | Amoxicillin | 3.7 | 0.58 | 0.88 | 22% | 100% | – | – | [73] |
| PMMA:Nylon6 1/1 | Ampicillin | 20 | 0.87 | 1.48 | 100ug/mL | 300ug/mL | 600ug/mL | 800ug/mL | [67] |
a
Scifinder, substance identifier: calculated using Advanced Chemistry Development (ACD/Labs) software v11.02; (accessed Jul 04, 2015).
b
DrugBank v4.3: calculated using ALOGPS v2.1; (accessed Jul 04, 2015).