FIG. 3.

Oral burdens of C. albicans in CD4C/HIV^MutA Tg mice and non-Tg controls. Mice were inoculated intraorally with 10⁸ CFU of C. albicans LAM-1, and burdens were assessed longitudinally by sampling the oral cavity. Oral burdens were strikingly elevated in Tg mice compared to control non-Tg mice during primary infection, the 6- to 10-week carrier state, and marked terminal outgrowth preceding death. In contrast, C. albicans was rapidly cleared from oral cavities of non-Tg mice immediately after primary infection. Oral burdens during primary infection in control non-Tg (A) and intact C3H mice (B; mean and standard deviation [SD]) were not significantly different (P > 0.05). There were six Tg and six non-Tg mice in the experiment in panel A and 42 C3H mice in the experiment in panel B. Adapted from reference 116 with permission of the publisher.