Table 1. Disruption of cortical zonation.
Constitutive activation of Wnt/β-catenin and ACTH/cAMP signaling results in disruption of functional zonation and affects cell identity.
| Wnt/β-catenin signaling | ACTH/cAMP signaling | |||
|---|---|---|---|---|
|
|
||||
| Normal Function | • Mineralocorticoid Synthesis | Heikkilä, 2002 | • Glucocorticoid Synthesis | Pulichino, 2003 |
| • CYP11B2, AT1R, NURR1, NUR77 | Kim, 2008 | • Cyp11b1, Mc2r, Mrap | Karpac, 2005 | |
| • Orthotopic zG | Berthon, 2014 | • Orthotopic zF | Chida, 2007 | |
| Constitutive Activation | ↑ Mineralocorticoid Synthesis | Berthon, 2014 | ↑ Glucocorticoid Synthesis | |
| ↓ Cyp11b1, Akr1b7 | Berthon, 2010 | • Expression of Cyp17 | Sahut-Barnola, 2010 | |
| Ectopic zG cells in zF | Walczak, 2014 | • Zonation defects | ||