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. Author manuscript; available in PMC: 2018 Jan 12.
Published in final edited form as: Cell. 2016 Nov 17;168(1-2):20–36. doi: 10.1016/j.cell.2016.10.044

Figure 5.

Figure 5

Strategies for in vivo delivery of CRISPR-based genome editing agents. (a) Viral (orange)-, lipid nanoparticle (green)-, and direct nucleic acid injection (blue)-mediated delivery of CRISPR-based genome editing agents have all been successfully used to achieve in vivo genome editing. (b) These methods have been used to deliver genome editing agents to a variety of mammalian organs shown. The genes that were modified within each organ are shown in a color corresponding to the delivery method used, matching the colors in (a).

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