Table 3.
22-year associations (β coefficient and 95% CI) between pre- and postnatal MeHg exposure and CANTAB cognitive outcomes*ˆ
| Outcome † | Prenatal model | Pre- and Postnatal model | |||
|---|---|---|---|---|---|
|
| |||||
| N | Prenatal MeHg‡ | N | Prenatal MeHg‡ | Postnatal MeHg‡ | |
| RT | |||||
| 5-choice accuracy ↑ | 470 | -0.04 (-0.10, 0.03) | 441 | -0.04 ( -0.11, 0.03) | -0.01 ( -0.09, 0.07) |
| 5-choice reaction time (inverse)a | 470 | 0.01 (0.00, 0.02) | 441 | 0.01 (-0.00, 0.02) | -0.01 (-0.02, 0.00) |
| IED | |||||
| Total errors adjusted (log) ↓ | 470 | 4.22 (-9.87, 18.30) | 441 | -0.02 (-14.79, 14.74) | 25.63 (8.58, 42.68) |
| Stages completed ↑ | 470 | -0.03 (-0.07, 0.01) | 441 | -0.01 (-0.06, 0.03) | -0.05 (-0.10, -0.00) |
| Pre-ED errors (inverse) ↓ | 470 | -0.35 (-1.83, 1.12) | 441 | -0.35 (-1.89, 1.18) | -1.25 (-3.02, 0.52) |
| Completed stages errors+1 (log) ↓ | 468 | -10.23 (-23.68, 3.22) | 439 | -5.00 ( -19.05, 9.05) | -9.49 (-25.70, 6.72) |
| PAL | |||||
| Stages completed ↑ | 470 | 0.04 (-0.03, 0.12) | 441 | 0.08 (-0.01, 0.18) | -0.05 (-0.12, 0.04) |
| Total errors adjusted+1 (log) ↓ | 470 | -1.05 (-17.56, 15.47) | 441 | -4.24 (-21.25, 12.77) | 13.82 (-5.82, 33.45) |
| Stages completed on first trial ↑ | 470 | 0.01 (-0.03, 0.05) | 441 | 0.01 (-0.04, 0.05) | -0.01 (-0.06, 0.04) |
| DMS | |||||
| % correct 0 ms delay ↑ | 470 | -0.00 (-0.04, 0.04) | 441 | -0.00 (-0.04, 0.04) | 0.03 (-0.02, 0.08) |
| % correct 4 ms delay ↑ | 470 | 0.02 (-0.02, 0.06) | 441 | 0.02 (-0.02, 0.06) | 0.01 (-0.04, 0.06) |
| % correct 12 ms delay ↑ | 470 | 0.04 (0.00, 0.08) | 441 | 0.05 (0.01, 0.09) | -0.03 (-0.07, 0.01) |
| % correct simultaneous ↑ | 470 | 0.00 ( -0.06, 0.07) | 441 | 0.02 ( -0.05, 0.10) | 0.05 (-0.04, 0.15) |
| RVP | |||||
| Total misses ↓ | 470 | 0.01 (-0.10, 0.11) | 441 | -0.00 ( -0.11, 0.11) | 0.00 (-0.13, 0.13) |
| Total false alarms+1 (log) ↓ | 470 | 2.16 (-19.35, 23.67) | 441 | 5.01 ( -17.36, 27.37) | 20.32 (-5.50, 46.13) |
| Mean latency (inverse) ↓ | 469 | -0.00 (-0.01, 0.01) | 440 | -0.01 (-0.02, 0.01) | -0.00 (-0.02, 0.01) |
| SWM | |||||
| Strategy ↓ | 470 | -0.05 ( -0.13, 0.03) | 441 | -0.06 ( -0.15, 0.02) | 0.02 ( -0.07, 0.12) |
| Between errors (square root) ↓ | 470 | -0.00 (-0.04, 0.04) | 441 | -0.01 (-0.06, 0.04) | 0.01 (-0.04, 0.06) |
| Within errors+1 (inverse) ↓ | 470 | -5.02 (-12.08,2.05) | 441 | -5.86 (-13.20,1.47) | 0.40 (-8.06,8.87) |
| Total errors (square root) ↓ | 470 | -0.00 (-0.04, 0.04) | 441 | -0.01 ( -0.05, 0.04) | 0.01 (-0.04, 0.06) |
| SOC | |||||
| 3 move problem ↓ | 470 | -0.01 (-0.05, 0.03) | 441 | -0.01 (-0.05, 0.03) | -0.01 (-0.06, 0.04) |
| 4 move problem (log) ↓ | 470 | -0.27 (-4.14, 3.59) | 441 | -0.49 (-4.59, 3.61) | -1.82 (-6.55, 2.92) |
| 5 move problem (log) ↓ | 470 | -5.11 (-9.25, -0.97) | 441 | -5.59 (-9.92, -1.25) | 0.86 ( -4.14, 5.87) |
Regression coefficients and 95% confidence intervals. Regression coefficients scaled by 1,000 for log and inverse transformed outcomes. All models are adjusted for child sex, maternal KBIT, and SES.
Logistic regression models: RT 5-choice accuracy, DMS simultaneous; proportional odds models: IED stages completed, PAL stages completed, PAL stages completed on first trial, DMS 0, 4 and 12 ms delay, SOC 3 move problem; All other models are linear regression models.
arrows indicate direction of better performance (↓ = lower scores are better; ↑ = higher scores are better). Applied transformation, where necessary, in parentheses.
Regression coefficients that are statistically significant (p<0.05) are bolded.
RT scores indicate response speed and not necessarily better or worse.