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. Author manuscript; available in PMC: 2018 Feb 5.
Published in final edited form as: Mol Cell Endocrinol. 2016 Aug 24;441:68–75. doi: 10.1016/j.mce.2016.08.035

Figure 3.

Figure 3

Ribbon representation of crystal structure of CYP17A1 highlighting characteristic structural features. A. Structure of progesterone (black sticks) bound CYP17A1 A105L mutant (PDB id: 4nkx) showing typical P450 structural folds with iron coordinated heme in the active site. B. Overlay of the two molecules of CYP17A1 A105L from one crystal symmetric unit is shown. A/B (shown in dark cyan) and C/D (gold) highlight the variation in the backbone structure of helix F and G structure, which interacts with the ER membrane.