Table 3.
BCATm activity and body composition of WT and LivTg-HE mice before (0 weeks) and after 12 weeks of high fat diet (HFD)
| 0 weeks | 12 weeks | |||
|---|---|---|---|---|
| WT | LivTg-HE | WT-HFD | LivTg-HE-HFD | |
| BCATm activity (U/mg) | - | - | <0.0 ± 0.0 | 0.7a ± 0.1 |
| Body fat (% of BW) | 5.1 ± 0.5 | 5.5 ± 0.3 | 25.0b ± 1.4 | 26.0c ± 1.2 |
| Lean mass (% of BW) | 77.5 ± 0.6 | 77.9 ± 0.6 | 57.9b ± 1.2 | 56.1c ± 1.1 |
| Fluid (% of BW) | 6.9 ± 0.1 | 6.9 ± 0.1 | 8.7b ± 0.2 | 8.6c ± 0.1 |
Body fat, lean mass, and fluid were measured after 0, 3, 9 and 12 weeks of high fat diet feeding. The data from 0 and 12 weeks are shown. Data represent mean ± SEM, n=6–12 male mice,
a
P≤0.05 as compared to WT-HFD mice,
b,c
P≤0.05 as compared to WT or LivTg-HE mice at 0 weeks of high fat diet, respectively. BW, body weight.