Table 1.

Donor Variables Examined for Univariate Association with RNA Quality Outcome

Name	≤4.5 RIN		≥6.5 RIN		Odds Ratio	95% CI	p-value

	n	% or Value^A	n	% or Value^A

Cause of Death							0.03
Anoxia	20	37%	34	63%	-	-	-
Cerebrovascular/Stroke^B	19	56%	15	44%	0.46	(0.19–1.11)	0.09
Head Trauma	29	63%	17	37%	0.35	(0.15–0.77)	0.01
Other^C	6	75%	2	25%	0.20	(0.03–0.94)	0.06

C-peptide^D,^E (ng/mL)	69	2.01 (0.00,26.42)	64	0.44 (0.00,23.18)	0.95	(0.88–1.01)	0.10

Pancreas Lipase^E,^F (u/L)
Normal	41	51%	39	49%	-	-	-
Elevated or Critical	16	67%	8	33%	0.526	(0.19–1.34)	0.18

Pancreas Amylase^E,^F (u/L)							0.59
Normal	41	58%	30	42%	-	-	-
Low	6	43%	8	57%	1.82	(0.58–6.06)	0.31
Elevated or Critical	10	56%	8	44%	1.09	(0.38–3.10)	0.87

Kidney Creatinine^E,^F (mg/dL)							0.71
Normal	34	56%	27	44%	-	-	-
Low	3	43%	4	57%	1.68	(0.34–9.13)	0.52
Elevated or Critical	29	59%	20	41%	0.87	(0.40–1.86)	0.72

Blood pH^E	72	7.4 (±0.2)	64	7.4 (±0.1)	2.09	(0.17–67.36)	0.57

Hematocrit^E,^F (%)
Normal	9	69%	4	31%	-	-	-
Low	63	51%	60	49%	2.14	(0.66–8.25)	0.21

Number and % are reported for all categorical variables. Use of mean (± 1 SD) or median (min, max) for continuous variables.

Donors with cause of death originally noted as cerebral edema (1) and other:cardiovascular (1) were grouped into this category.

Includes perinatal condition/birth defect (2), meningitis (2), spinal cord injury (1), cystic fibrosis (1), respiratory distress/failure (1), and diabetic ketoacidosis (1).

A fill value of 0.001 was used when assay results <0.05 (lower limit of detection)

Taken within 24 hrs prior to or at death

Age and sex specific cut offs adopted using previously published reference values for adults & pediatric populations.^44,45 Critical values defined as more than 3 times the upper limit of normal.⁵⁴ Elevated and critical groups combined due to small sample sizes