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Sumatriptan had no effect on wheel running in rats not treated with AITC. a Wheel running was variable following administration of sumatriptan (1 mg/kg) or saline (1 mL/kg) in the absence of headache. Neither sumatriptan (n = 14) nor saline (n = 18) depressed wheel running. b Wheel running was unaffected in the 3 h following sumatriptan or saline
