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. 2017 Jan 12;168(1-2):86–100.e15. doi: 10.1016/j.cell.2016.11.010

Figure 4.

Figure 4

Hormone Secretion Controls Pancreatic Cell-type Stability

(A) ELISA for secreted glucagon in αTC1 cells treated with 10 μM artemether for 72 hr (n = 4). ∗p < 0.05. Error bars represent mean ± SD.

(B) Immunofluorescence quantification of insulin intensity in αTC1 cells with treated with 10 μM artemether and 10 ng/ml glucagon for 72 hr (n = 4). ∗p < 0.001. Error bars represent mean ± SD.

(C) Representative images of insulin and glucagon immunofluorescence in αTC1 cells treated with 10 μM prohormone convertase inhibitor (PCi) for 72 hr. Scale bars, 5 μm.

(D) qRT-PCR of islet genes in αTC1 cells following treatment with 10 μM PCi for 72 hr. All data were normalized to DMSO control (n = 3). ∗p = 0.010; ∗∗p = 0.019; ∗∗∗p = 0.002; ∗∗∗∗p < 0.001. Error bars represent mean ± SD.