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. 2017 Jan 12;168(1-2):86–100.e15. doi: 10.1016/j.cell.2016.11.010

Figure 7.

Figure 7

Artemether Enhances Insulin Secretion in Human Islets

(A) RT-qPCR assay for ARX expression in human islets treated with control DMSO or 10 μM artemether for 72 hr. Error bars represent mean ± SD.

(B) Measurement of intracellular insulin content in human islets treated with control DMSO or 10 μM artemether for 72 hr. Error bars represent mean ± SD.

(C) Measurement of glucose-stimulated insulin secretion in human islets treated with control DMSO or 10 μM artemether for 72 hr (two replicates each donor; ∗∗p < 0.005; ∗p ≤ 0.05). Error bars represent mean ± SD.

(D) Proposed mechanism of action of artemether. By stabilizing gephyrin, artemether increases GABA-receptor signaling in α cells, thereby preventing glucagon secretion. Decreased extracellular glucagon concentration induces loss of α cell identity and increase of insulin expression.

See also Figure S6.