Figure S5.

Effect of Artemether on Pancreatic Islets In Vivo, Related to Figure 5

(A) Islet morphology and GFP expression as marker of α cells of Tg(Gcga:GFP)^ia1 zebrafish larvae treated from 26 hpf until 100 hpf with artemether.

(B) Quantification of Glucagon-GFP positive cells and Insulin-mCherry positive cells per single zebrafish islets (8-10 fish per condition; ^∗p = 0.007, ^∗∗p = 0.088, ^∗∗∗p = 0.004, ^∗∗∗∗p = 0.003). Error bars represent mean ± SD.

(C) Immunofluorescence for Sst, Pp, and BrdU co-stained with insulin or glucagon in mouse pancreas with or without artemether treatment.