REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Insulin	Sigma	Cat#18510
	Dako	Cat#A056401; RRID: AB_2617169
	Linko	Cat#4011-01
Glucagon	Abcam	Cat#ab92517; RRID: AB_10561971
Arx	R&D	Cat#AF7068; RRID: AB_10973178
Myc-Tag	Cell Signaling Technology	Cat#2276
Histone H2B	Cell Signaling Technology	Cat#2934
Gephyrin	Abcam	Cat#ab25784; RRID: AB_1209349
Gephyrin (Figure S4B)	Synaptic systems	Cat#147111; RRID: AB_887719
GABA-receptor subunit beta 3/4	Millipore	Cat#MAB341; RRID: AB_2109419
GABA-receptor subunit alpha 2	Abcam	Cat#ab176170
GABA-receptor subunit gamma 2	Abcam	Cat#ab101036; RRID: AB_10672116
mTOR	Cell Signaling Technology	Cat#2972
p-mTOR	Cell Signaling Technology	Cat#5536
Akt	Cell Signaling Technology	Cat#4691
p-Akt	Cell Signaling Technology	Cat#4060P; RRID: AB_972551
Actin	Sigma	Cat#A2066; RRID: AB_476693
Alpha-Tubulin	Abcam	Cat#ab7291; RRID: AB_2241126
dsRed	Clontech	Cat#632496; RRID: AB_10013483
Goat Anti-rabbit 633	Thermo Fischer	Cat#A-21070; RRID: AB_2535731
Goat Anti-Guinea Pig 546	Thermo Fischer	Cat#A-11074; RRID: AB_2534118
Goat Anti-Guinea Pig 488	Thermo Fischer	Cat#A-11073; RRID: AB_2534117
Donkey Anti-Rabbit 488	Thermo Fischer	Cat#A-21206; RRID: AB_2535792
Donkey Anti-Mouse 488	Thermo Fischer	Cat#A-21202; RRID: AB_2535788
Donkey Anti-Sheep 546	Thermo Fischer	Cat#A-21098; RRID: AB_2535752
Donkey anti-Rabbit 546	Thermo Fischer	Cat#A-10040/A-10036/A-10074; RRID: AB_2534016
Rabbit anti-sheep IgG-HRP	Santa Cruz	Cat#SC-2770; RRID: AB_656968
Donkey Anti-Rabbit HRP	Jackson ImmunoResearch	Cat#711-035-152; RRID: AB_10015282
Donkey Anti-Mouse HRP	Jackson ImmunoResearch	Cat#715-035-151; RRID: AB_2340771
Donkey Anti-Sheep HRP	Jackson ImmunoResearch	Cat#713-035-147; RRID: AB_2340771
Donkey Anti-Goat HRP	Jackson ImmunoResearch	Cat#705-035-147; RRID: AB_2313587
Chemicals, Peptides, and Recombinant Proteins
Artemether	Sigma	Cat#A9361
Artemether (Figures 5H–5J)	Cayman Europe	Cat#11815
Bicuculline	Tocris	Cat#0130
Gabazine	Sigma	Cat#S106
Picrotoxin	Sigma	Cat#P1675
Salicylidene salicylhydrazide	Sigma	Cat#S8194
Etifoxine	Sigma	Cat#SML0272
Muscimol	Sigma	Cat#M1523
Vgabatrin	Sigma	Cat#V8261
Halothane	MedChemExpress	Cat#HY-B1010
NS11394	MedChemExpress	Cat#HY-11048
Zolpidem	Sigma	Cat#E006
Thapsigargin	Sigma	Cat#T9033
Gaboxadol	Santa Cruz	Cat#sc204342
Furosemide	Tocris	Cat#3109
FG-7142	Sigma	Cat#E006
Elesclomol	Selleck	Cat#S1052
Nacetylcysteine	Sigma	Cat#A9165
Lynxtag_art	Biolynx Technologies	Cat#BL007RUO
PCi	Enzo Life Sciences	Cat#ALX-260-022-M001
Artesunate	Sigma	Cat#A3731
Artesunate (Figures 5D and E)	TCI	Cat#A2191
Deoxyarteether	Santa Cruz	Cat#sc-211235
Arteether	Santa Cruz	Cat#sc-217662
N-hydroxy-11-azaartemisinin	TRC	Cat#H804500
Artemisitene	TRC	Cat#A777550
Artemisone	Alsachim	Cat#C1740
Artemisiten	Alsachim	Cat#S1873
Dihydro artemisinin	TRC	Cat#A637875
Recombinant glucagon	Sigma	Cat#G2044
Dimerizer AP20187	Clontech	Cat#635059
pE2-Crimson-N1 Vector	Clontech	Cat#632554
Methylcellulose	Sigma	Cat#M6385
Hoechst 33342	Thermo Fischer	Cat#H1399
Critical Commercial Assays
Xanthine Oxidase Assay Kit	Abcam	Cat#ab102522
PI(3)P Mass ELISA kit	Echelon	Cat#K-3300
Glucagon ELISA	Alpco	Cat#48-GLUHU-E01-AL
Insulin ELISA	Alpco	Cat#80-INSHU-E01.1
Glucose Assay Kit	Biovision	Cat#K606-100
Deposited Data
Single cell RNA-seq of the control cells	NCBI Gene Expression Omnibus	GEO: GSE73727
Single cell RNA-seq of the artemether treated cells	NCBI Gene Expression Omnibus	GEO: GSE84714
RNA-seq of bulk samples	NCBI Gene Expression Omnibus	GEO: GSE84592
Experimental Models: Cell Lines
αTC1	Novo Nordisk	ATCC Cat#CRL-2934
αTC1-LT	This paper	N/A
Min6	Novo Nordisk	Miyazaki et al., 1990
Min6-ARX	This paper	N/A
Experimental Models: Organisms/Strains
(Gcga:GFP)ia1- (Ins:NTR-mcherry)ml10 Zebrafish	This paper	N/A
Ins:caspase8;ins:E2Crimson Zebrafish	This paper	N.S. and D.M., unpublished data
GluCre::RFP mouse	This paper	N/A
Recombinant DNA
TetR-CMV-ARX-MYC-FLAG	This paper	N/A
SV40 large T-antigen lentivirus	GenTarget	Cat#LVP016-Neo
Sequence-Based Reagents
Primers for Ins2, Actb, Pax4, ACTB	Fomina-Yadlin et al., 2010	N/A
Primers for Mnx1, Gcg, ARX	This paper	Table S2
shGephyrin	Sigma	Cat#TRCN0000098585
shControl	Sigma	Cat#SHC001
Software and Algorithms
Tophat v2.0.4	Kim et al., 2013	https://ccb.jhu.edu/software/tophat/index.shtml
RSeQC package	Wang et al., 2012	http://rseqc.sourceforge.net/
Gene Set Enrichment Analysis	Subramanian et al., 2005	http://software.broadinstitute.org/gsea/downloads.jsp
	Mootha et al., 2003
ImageJ/FIJI	Schneider et al., 2012	https://fiji.sc/
Cell Counter Plugin	Kurt De Vos, University of Sheffield, Academic Neurology	https://imagej.nih.gov/ij/plugins/cell-counter.html