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. 2016 Oct 26;34(2):243–256. doi: 10.1007/s11095-016-2043-9

Fig. 3.

Fig. 3

Number and type of KM tools for solving specific QbD-related applications. KM tools based on data mining, taxonomies and intelligent agents are the most used tools and are mainly based on data driven algorithms. Mechanistic approaches such as model and simulations have an increasing trend but are less used so far.