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. 2016 Nov 18;34(2):333–351. doi: 10.1007/s11095-016-2065-3

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© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — Human brain_ECF and CSF concentration-time profiles (circles) and prediction from the translational model (red lines: median, shaded area is 95% prediction interval). (a) Acetaminophen data was obtained from plasma, CSF_SAS and CSF_EVD, (b) morphine data was obtained from plasma and brain_ECF in “normal” brain and “injured” brain. The x-axis represents the time in minutes and the y-axis represents the acetaminophen and morphine concentration in ng/ml. The panels are stratified by brain compartments and brain conditions.