Table II.
Summary of the Human Acetaminophen and Morphine Data
| Study design | Acetaminophen | Morphine | |||
|---|---|---|---|---|---|
| Study 1 | Study 2 | Study 1 | Study 2 | ||
| Condition of patients | human with traumatic brain injury | human with nerve-root compression pain | human with traumatic brain injury | human with traumatic brain injury | |
| Nr of patients | 7 | 1 (mean values) | 2 | 1 | |
| Dosage | 1 g, 30 min infusion | 2 g (propacetamol), short infusion | 10 mg, 10 min infusion | 10 mg, 10 min infusion | |
| Nr of samples (sampling time, h) | plasma | 38 (0–6 h) | 11 (0–12 h) | 23 (0–3 h) | 11 (0–3 h) |
| brain ECF or CSF | 54 (0–5.5 h) | 11 (0–13 h) | 74 (0–3 h) | 37 (0–3 h) | |
| data references | Newly generated | (31) | (34) | (33) | |
| Data | |||||
| plasma | X | X | X | X | |
| brainECF | X (“normal” and “injured” brain tissue) | X (“normal” and “injured” brain tissue) | |||
| CSFEVD | X | ||||
| CSFSAS | X | ||||
| fp a | 85% | 85% | – | – | |
| fp references | (32) | (32) | (34) | (33) | |
brain ECF a brain extracellular fluid compartment, CSF EVD a compartment of cerebrospinal fluid in EVD, CSF SAS a compartment of cerebrospinal fluid in subarachnoid space
a free fraction in plasma