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Fat alters the metabolic capacity of hepatocytes. Hepatocytes were cultured in fat or lean conditions for 7 d. A: CYP3A activity was measured in three donors by CYP3A-Glo assay (n = 3 per donor); B: P450 activity of cells was compared using an LC-MS/MS cocktail assay. Production of key metabolites from probe compounds was measured after 2 h exposure and normalised to total cellular protein content. Data is a mean (n = 3) ± SD, aP < 0.05.
