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. 2017 Jan 14;23(2):275–285. doi: 10.3748/wjg.v23.i2.275

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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Small hyperfunctioning pancreatic neuroendocrine neoplasm (insulinoma) classified as G1, stage 1 tumor at histology (Ki67 < 1%, T1, N0, M0) in a 44 years-old woman. A: Axial volumetric interpolated breath-hold examination (VIBE) gradient echo image (repetition time msec/echo time msec, 4.3/1.4) with fat suppression shows a homogeneously hypointense lesion with well defined margins (arrow) in the pancreatic body; B: On axial T2-weighted half-Fourier single-shot turbo spin echo (HASTE) image (TR/TE, ∞/90), the tumor appears slightly hyperintense (arrow) compared to adjacent pancreatic parenchyma; C: At ADC quantification the tumor had a relatively high mean ADC value; D: The macroscopic pathological specimen (distal pancreatectomy, sagittal cut) shows a small, well-delimitated lesion bulging the contour of the pancreatic body.