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. 2017 Jan 13;10:24. doi: 10.1186/s13071-016-1944-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Cellular pathways of I. scapularis proteins and possible roles in the LGTV life-cycle inferred from RNAi data. VNN, MDH2, PARP, and Hypo195 exhibited increased expression following LGTV infection only (blue text). FAH, ERP29, ALDH, CMPK, ACAT1, and Hypo576 (magenta text) exhibited increased expression following LGTV infection and/or UV-LGTV treatment [4]. CMPK: orange arrow, VNN: red arrows, ACAT1: blue arrows, FAH: green arrows, ALDH: purple arrow, MDH2: brown arrow, ERP29: black arrow, Hypo576: gray arrows, and Hypo195: pink arrows. Cellular pathways were inferred based on the classification of ISE6 proteins by KEGG PATHWAY analysis and RNAi data (pre-treatment and post-treatment with dsRNA; Fig. 2b-d; Table 2)