Table 4.
Correlation between the changes of LDL-C subspecies, HDL-C subspecies and the changes of lipid parameters
| Dapagliflozin | Sitagliptin | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ΔLDL-C (mg/dL) | Δsd LDL-C (mg/dL) | Δlb LDL-C (mg/dL) | ΔLDL-C (mg/dL) | Δsd LDL-C (mg/dL) | Δlb LDL-C (mg/dL) | |||||||
| r | p | r | p | r | p | r | p | r | p | r | p | |
| ΔTG (mg/dL) | 0.085 | 0.604 | 0.008 | 0.959 | 0.055 | 0.736 | 0.125 | 0.430 | 0.155 | 0.345 | −0.009 | 0.953 |
| ΔLDL-C (mg/dL) | 0.080 | 0.625 | 0.665 | <0.001* | 0.425 | 0.006* | 0.507 | 0.001* | ||||
| Δsd LDL-C (mg/dL) | 0.080 | 0.625 | −0.690 | <0.001* | 0.425 | 0.006* | −0.324 | 0.043* | ||||
| Δlb LDL-C (mg/dL) | 0.665 | <0.001* | −0.690 | <0.001* | 0.507 | 0.001* | −0.324 | 0.043* | ||||
| Δapo AI (mg/dL) | 0.320 | 0.046* | 0.280 | 0.084 | 0.022 | 0.890 | 0.301 | 0.073 | 0.044 | 0.795 | 0.013 | 0.938 |
| Δapo AII (mg/dL) | 0.466 | 0.002* | 0.270 | 0.095 | 0.135 | 0.410 | 0.584 | <0.001* | 0.241 | 0.150 | 0.198 | 0.238 |
| Δapo B (mg/dL) | 0.894 | <0.001* | 0.078 | 0.639 | 0.592 | <0.001* | 0.909 | <0.001* | 0.467 | 0.003* | 0.377 | 0.021* |
| Δapo CIII (mg/dL) | 0.316 | 0.049 | 0.247 | 0.128 | 0.044 | 0.787 | 0.287 | 0.084 | 0.451 | 0.005* | −0.135 | 0.422 |
| ΔHDL-C (mg/dL) | ΔHDL2-C (mg/dL) | ΔHDL3-C (mg/dL) | ΔHDL-C (mg/dL) | ΔHDL2-C (mg/dL) | ΔHDL3-C (mg/dL) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| r | p | r | p | r | p | r | p | r | p | r | p | |
| ΔTG (mg/dL) | −0.156 | 0.341 | −0.125 | 0.446 | −0.069 | 0.674 | −0.176 | 0.277 | −0.074 | 0.646 | −0.228 | 0.155 |
| ΔLDL-C (mg/dL) | 0.295 | 0.067 | 0.167 | 0.306 | 0.239 | 0.142 | 0.555 | <0.001* | 0.254 | 0.113 | 0.307 | 0.053 |
| Δsd LDL-C (mg/dL) | 0.183 | 0.262 | −0.066 | 0.688 | 0.411 | 0.009* | 0.192 | 0.240 | −0.036 | 0.825 | 0.392 | 0.013* |
| Δlb LDL-C (mg/dL) | 0.760 | 0.641 | 0.171 | 0.297 | −0.134 | 0.413 | 0.288 | 0.071 | 0.561 | <0.001* | 0.307 | 0.053 |
| Δapo AI (mg/dL) | 0.890 | <0.001* | 0.697 | <0.001* | 0.450 | 0.004* | 0.808 | <0.001* | 0.516 | 0.002* | 0.489 | 0.003* |
| Δapo AII (mg/dL) | 0.647 | <0.001* | 0.394 | 0.012* | 0.500 | 0.001* | 0.633 | <0.001* | 0.354 | 0.034* | 0.446 | 0.007* |
| ΔapoB (mg/dL) | 0.283 | 0.080 | 0.240 | 0.141 | 0.105 | 0.522 | 0.368 | 0.019* | 0.135 | 0.406 | 0.230 | 0.153 |
| ΔapoCIII (mg/dL) | 0.309 | 0.055 | 0.234 | 0.149 | 0.156 | 0.340 | 0.132 | 0.415 | 0.026 | 0.871 | 0.100 | 0.538 |
r coefficient of correlation, TG triglycerides, LDL-C low-density lipoprotein-cholesterol, sd LDL-C small dense LDL-cholesterol, lb LDL-C large buoyant LDL-cholesterol, Apo apolipoprotein, HDL-C high-density lipoprotein-cholesterol, HDL2-C high-density lipoprotein 2-cholesterol, HDL3-C high-density lipoprotein 3-cholesterol
* p < 0.05