Table 3.

Genotype and allele frequencies of atherosclerotic gene variants in the study population

SNP	Genotypes	Controls (n = 34)	Patients (n = 23)	P values	Crude OR (95% CI)	Adjusted OR (95% CI)
FGB	Normal	22 (64.7)	12 (52.2)	0.636	1.0	1.0
-455G > A	Hetero	10 (29.4)	9 (39.1)		1.6 (0.5–5.2)	0.28 (0.02–3.1)
	Homo	2 (5.9)	2 (8.7)		1.8 (0.2–14.7)	1.65 (0.1–20.2)
	Dominant model	12 (35.3)	11 (47.8)		1.6 (0.5–4.9)
	p HWE	0.557	0.866
	MAF (A)	0.21	0.28	0.344	1.5 (0.6–3.6)
HPA-1	a/a	26 (76.5)	13 (56.5)	0.112	1.0	1.0
a/b	a/b	8 (23.5)	8 (34.8)		2.0 (0.6–6.5)
	b/b	0 (0.0)	2 (8.7)		9.8 (0.4–21.9)	4.0 (1.4–6.4)
	Dominant model	8 (23.5)	10 (43.5)		2.5 (0.7–7.8)
	p HWE	0.436	0.638
	MAF (b)	0.12	0.26	0.048	2.6 (0.9–7.1)
ACE	I/I	6 (17.6)	2 (8.7)	<0.001	1.0	1.0
I/D	I/D	26 (76.5)	9 (39.1)		1.0 (0.1–6.1)	2.79 (0.3–29.7)
	D/D	2 (5.9)	12 (52.2)		18 (2.0–161)	88.3 (4.3–179)
	Dominant model	28 (82.4)	21 (91.3)		2.3 (0.4–12.2)
	p HWE	0.001	0.866
	MAF (D)	0.44	0.72	0.003	3.2 (1.4–7.1)
ApoB	Normal	34 (100)	23 (100)	NA	NA
R3500Q	p HWE	NA	NA
ApoE	E2/E2	0 (0.0)	1 (4.3)	0.009	1.0
E2/E3/E4	E2/E4	2 (5.9)	1 (4.3)		0.2 (0.0–8.8)
	E2/E3	20 (58.8)	3 (13.0)		0.05 (0.0–1.6)
	E3/E3	10 (29.4)	15 (65.2)		0.4 (0.01–13.2)
	E3/E4	2 (5.9)	3 (13.0)		0.4 (0.01–16.8)
	p HWEa	0.060	0.550
	E3	0.61	0.78	0.004	1.0
	E2	0.32	0.13		0.08 (0.04–0.18)
	E4 (MAF)	0.06	0.09		0.61 (0.2–1.87)

FGB fibrinogen beta polypeptide chain, HPA-1 human platelet antigen 1, ACE angiotensin converting enzyme, ApoB Apolipoprotein B-100, ApoE apolipotprotein E, ^aThe number of degrees of freedom for the chi-square is equal to 3 for three allele systems and 1 for two allele systems. MAF minor allele frequency. Fisher’s Exact and Chi-square tests were used. Adjusted OR by potential confounders (gender, age, BMI, FH, DM, obesity). Bold values indicate statistically significant at p < 0.05