Table 4.
Haplotype frequencies and genotype combinations of both F5: Leiden 1691G > A with F5: R2 4070A > G, and MTHFR 667C > T with 1298A > C polymorphisms in CAD patients and controls
| Haplotypesa | Overall frequency | Controls (n = 34) | Patients (n = 23) | P values | OR (95% CI) |
|---|---|---|---|---|---|
| Genotype combination: MTHFR 667C > T/1298A > C | |||||
| CC-AA | 11 (19.3) | 8 (23.5) | 3 (13.0) | 0.150 | Reference |
| CT-AA | 3 (5.3) | 2 (5.9) | 1 (4.3) | 1.3 (0.08–20.7) | |
| TT-AA | 4 (7.0) | 0 (0.0) | 4 (17.4) | 21.8 (0.9–523) | |
| CC-AC | 9 (15.8) | 6 (17.6) | 3 (13) | 1.3 (0.19–9.08) | |
| CT-AC | 14 (24.6) | 10 (29.4) | 4 (17.4) | 1.06 (0.18–6.2) | |
| TT–AC | 1 (1.8) | 0 (0.0) | 1 (4.3) | 7.2 (0.23–225) | |
| CC-CC | 14 (24.6) | 8 (23.5) | 6 (26.1) | 2.0 (0.3–10.9) | |
| CT-CC | 1 (1.8) | 0 (0.0) | 1 (4.3) | 7.2 (0.23–225) | |
| Genotype combination: FVL 1691G > A/FVR 4070A > G | |||||
| GG-AA | 41 (71.9) | 28 (82.4) | 13 (56.5) | 0.080 | Reference |
| GG-AG | 11 (19.3) | 4 (11.8) | 7 (30.4) | 3.7 (0.9–15.18) | |
| GA–AA | 3 (5.3) | 2 (5.9) | 1 (4.3) | 1.07 (0.08–12.9) | |
| GA-AG | 2 (3.5) | 0 (0.0) | 2 (8.7) | 10.5 (0.47–235) | |
| Block 1: MTHFR 667C > T/1298A > C | |||||
| CC | 0.446 | 45.9 | 42.8 | 0.7437 | |
| CA | 0.308 | 36.5 | 22.4 | 0.1114 | |
| TA | 0.218 | 16.5 | 29.8 | 0.0926 | |
| TC | 0.027 | 1.1 | 5 | 0.2134 | |
| Block 2: FVL 1691G > A/FVR 4070A > G | |||||
| GA | 0.856 | 91.2 | 77.4 | 0.0397 | |
| GG | 0.1 | 5.9 | 16.1 | 0.075 | |
| AA | 0.03 | 2.9 | 3 | 0.9767 | |
| AG | 0.014 | 0 | 3.5 | 0.121 | |
MTHFR, Methylenetetrahydrofolate reductase; FV, coagulation factor 5
aHaploview version 4.1 was used for data analysis. Bold values indicate statistically significant at p < 0.05