Table 2.
Resistance profiles of the 10 samples presenting a dual infection HIV-1/M+O and/or a HIV-1/MO recombinant form
Samples | Profile | Protease | RT | Resistance associated mutations and resistance interpretationa | |||||
---|---|---|---|---|---|---|---|---|---|
HIV-1/M species | HIV-1/O species | ||||||||
Protease | RT | Resistance profileb | Protease | RT | Resistance profile | ||||
YBF221 | Dual | M + O | M + O | K20I M36I L63P/L L89M | V90I | L10V L33I M36I M46L/M I62V A71V K20C L63T L89T | T69S M184V A98G V179E Y181C L210Y | ATV, IDV, 3TC/ FTC, NNRTI LPV, SQV, ABC | |
YBF280 | Dual | M + O | M + O | K20I M36I V77I L89M | None | L10V V11I I15V M36I I62V A71V K20C D60N/S L63I L89I | A98G K103R V179E L210Y | SQV ATV | |
YBF301 | Dual | M + O | M + O | L10V K20I L24L/I M36I L89M | None | SQV | L10V I15V M36I I62V A71V K20C L63T/A L89M | M184V A98G K103R V179E Y181C L210Y | SQV, 3TC/FTC, NNRTI ATV, ABC |
YBF320 | Dual | M + O | M + O | K20I M36I L89M | K101Q | L10I/V I15V M36I I62V A71V K20C L63T L89I | A98G V179E Y181C L210Y | SQV, NNRTI ATV | |
YBF211 | Dual + recombinant | M + O | M + O | I15L K20I M36I L63P L89M | None | L10V I15V M36I I62V A71V K20C L63T L89I | A98G V179E Y181C L210Y | SQV, NNRTI ATV | |
YBF212 | Dual + recombinant | M + O | M + O | K20I M36I L89M | E138A V179I K101Q | RPV ETR | L10I I15V L33V M36I I62V A71V/I K20C F53Y/C D60S L63A L89I | A98G V179E Y181C L210Y | ATV, SQV, NNRTI |
YBF205 | Dual + recombinant | M + O | O | K20I L24L/I M36I L89M | SQV | L10I I15V M36I I62V A71V K20C D60N/S L63T L89I | A98G K103R V179E L210Y | SQV ATV | |
YBF274 | Single + Recombinant | O | O | – | – | L10V/I I15V M36I D60E I62V A71V K20C L63T L89I | A98G V179E Y181C L210Y | ATV, SQV, NNRTI | |
YBF298 | Single + recombinant | M | M | K20I D30N M36I D60N G73S L89M | None | NFV SQV | – | – | – |
YBF282 | Recombinant alone | M | M | G16E K20I M36I L63P/L L89M | None | - | - |
aAccording to the ANRS resistance interpretation’s algorithm v25
bIn underline = resistance; italic = possible resistance